References
All of our product research is backed by science.
Our number one priority is to make supplements of the best quality possible, providing the right nutrients for your brain.
All references used during study, research and production of Brainrescue are summed up here.
Neuroinflammation general
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3. Herman, F. J., & Pasinetti, G. M. (2018). Principles of inflammasome priming and inhibition: implications for psychiatric disorders. Brain, behavior, and immunity, 73, 66-84.https://www.sciencedirect.com/science/article/pii/S0889159118302265
4. Block, M. L., Zecca, L., & Hong, J. S. (2007). Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience, 8(1), 57-69. https://www.nature.com/articles/nrn2038?r=1&l=ri&fst=0
5. Hickman, S., Izzy, S., Sen, P., Morsett, L., & El Khoury, J. (2018). Microglia in neurodegeneration. Nature neuroscience, 21(10), 1359-1369.https://www.nature.com/articles/s41593-018-0242-x
6. Norden, D. M., & Godbout, J. P. (2013). Microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathology and applied neurobiology, 39(1), 19-34.https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2990.2012.01306.x
7. Tay, T. L., Savage, J. C., Hui, C. W., Bisht, K., & Tremblay, M. È. (2017). Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. The Journal of physiology, 595(6), 1929-1945.https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP272134@10.1002/(ISSN)1469-7793.Experimental-Biology-2018
8. Wang, Y., & Kasper, L. H. (2014). The role of microbiome in central nervous system disorders. Brain, behavior, and immunity, 38, 1-12. https://www.sciencedirect.com/science/article/pii/S0889159113006004
9. Estes, M. L., & McAllister, A. K. (2016). Maternal immune activation: Implications for neuropsychiatric disorders. Science, 353(6301), 772-777. https://science.sciencemag.org/content/353/6301/772.abstract
10. Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., ... & Zhao, Y. (2017). Impact of aging immune system on neurodegeneration and potential immunotherapies. Progress in Neurobiology, 157, 2-28. https://www.sciencedirect.com/science/article/pii/S0301008215300484
11. Lynch, M. A., & Mills, K. H. (2012). Immunology meets neuroscience–opportunities for immune intervention in neurodegenerative diseases. Brain, behavior, and immunity, 26(1), 1-10.https://www.sciencedirect.com/science/article/pii/S0889159111001929
12. Ransohoff, R. M. (2016). How neuroinflammation contributes to neurodegeneration. Science, 353(6301), 777-783.https://science.sciencemag.org/content/353/6301/777.abstract
13. Allen, N. J., & Barres, B. A. (2009). Glia—more than just brain glue. Nature, 457(7230), 675-677.https://www.nature.com/articles/457675a
14. Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017). Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry. Translational Research, 179, 223-244. https://www.sciencedirect.com/science/article/pii/S193152441630264X
15. Yirmiya, R., Rimmerman, N., & Reshef, R. (2015). Depression as a microglial disease. Trends in neurosciences, 38(10), 637-658.https://www.sciencedirect.com/science/article/pii/S0166223615001769
16. Perrine, K., Helcer, J., Tsiouris, A. J., Pisapia, D. J., & Stieg, P. (2017). The current status of research on chronic traumatic encephalopathy. World Neurosurgery, 102, 533-544.https://www.sciencedirect.com/science/article/pii/S1878875017302577
17. Morris, G., Berk, M., Walder, K., & Maes, M. (2015). Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. BMC medicine, 13(1), 28.https://link.springer.com/article/10.1186/s12916-014-0259-2
18. El-Ansary, A., & Al Dera, H. (2016). Biomarkers directed strategies to treat autism. Role of Biomarkers in Medicine. In Tech Publisher, 205-28.https://books.google.com/books?hl=en&lr=&id=jG-QDwAAQBAJ&oi=fnd&pg=PA205&dq=biomarkers+directed+strategies+to+treat+autism&ots=-y9W8RFkRF&sig=hD6pupXDdzAPayqn0hR6CAHEwpQ
19. Calabrese, V., Santoro, A., Monti, D., Crupi, R., Di Paola, R., Latteri, S., ... & Franceschi, C. (2018). Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis. Free Radical Biology and Medicine, 115, 80-91.https://www.sciencedirect.com/science/article/pii/S0891584917311620
Clinical severity of neuroinflammation
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2. Schwab, J. M., Zhang, Y., Kopp, M. A., Brommer, B., & Popovich, P. G. (2014). The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury. Experimental neurology, 258, 121-129. https://www.sciencedirect.com/science/article/pii/S0014488614001253
3. Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017). Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron, 95(6), 1246-1265.https://www.sciencedirect.com/science/article/pii/S0896627317306128
4. Guerrero-García, J. D. J., Carrera-Quintanar, L., López-Roa, R. I., Márquez-Aguirre, A. L., Rojas-Mayorquín, A. E., & Ortuño-Sahagún, D. (2016). Multiple sclerosis and obesity: possible roles of adipokines. Mediators of inflammation, 2016. https://www.hindawi.com/journals/mi/2016/4036232/abs/
5. Li, J. W., Zong, Y., Cao, X. P., Tan, L., & Tan, L. (2018). Microglial priming in Alzheimer’s disease. Annals of translational medicine, 6(10).https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994530/
6. Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015). Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease. Neuropharmacology, 96, 29-41.https://www.sciencedirect.com/science/article/pii/S0028390814004031
7. Hoeijmakers, L., Heinen, Y., Van Dam, A. M., Lucassen, P. J., & Korosi, A. (2016). Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?. Frontiers in human neuroscience, 10, 398. https://www.frontiersin.org/articles/10.3389/fnhum.2016.00398/full
8. Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017). Microglia priming with aging and stress. Neuropsychopharmacology, 42(1), 318-333.https://www.nature.com/articles/npp2016185/
9. Block, M. L., & Hong, J. S. (2005). Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Progress in neurobiology, 76(2), 77-98.https://www.sciencedirect.com/science/article/pii/S0301008205000675
10. Loane, D. J., & Kumar, A. (2016). Microglia in the TBI brain: the good, the bad, and the dysregulated. Experimental neurology, 275, 316-327.https://www.sciencedirect.com/science/article/pii/S0014488615300790
11. Jin, X., & Yamashita, T. (2016). Microglia in central nervous system repair after injury. The Journal of Biochemistry, 159(5), 491-496.https://academic.oup.com/jb/article-abstract/159/5/491/1750705
12. Henriques, J. F., Portugal, C. C., Canedo, T., Relvas, J. B., Summavielle, T., & Socodato, R. (2018). Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity. Toxicology letters, 283, 21-31.https://www.sciencedirect.com/science/article/pii/S0378427417314509
13. Perry, V. H., & Teeling, J. (2013, September). Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. In Seminars in immunopathology (Vol. 35, No. 5, pp. 601-612). Springer Berlin Heidelberg.https://link.springer.com/article/10.1007/s00281-013-0382-8
14. Perry, V. H., & Teeling, J. (2013, September). Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. In Seminars in immunopathology (Vol. 35, No. 5, pp. 601-612). Springer Berlin Heidelberg. https://link.springer.com/article/10.1007/s00281-013-0382-8
15. Kiernan, E. A., Smith, S. M., Mitchell, G. S., & Watters, J. J. (2016). Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia. The Journal of physiology, 594(6), 1563-1577.https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP271502@10.1111/(ISSN)1469-7793.SLEEPVI
16. Kiernan, E. A., Smith, S. M., Mitchell, G. S., & Watters, J. J. (2016). Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia. The Journal of physiology, 594(6), 1563-1577.https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP271502@10.1111/(ISSN)1469-7793.SLEEPVI
17. Fumagalli, S., Perego, C., Pischiutta, F., Zanier, E. R., & De Simoni, M. G. (2015). The ischemic environment drives microglia and macrophage function. Frontiers in neurology, 6, 81.https://www.frontiersin.org/articles/10.3389/fneur.2015.00081/full
18. Sapin, E., Peyron, C., Roche, F., Gay, N., Carcenac, C., Savasta, M., ... & Dematteis, M. (2015). Chronic intermittent hypoxia induces chronic low-grade neuroinflammation in the dorsal hippocampus of mice. Sleep, 38(10), 1537-1546. https://academic.oup.com/sleep/article-abstract/38/10/1537/2468595
19. Collins-Praino, L. E., Arulsamy, A., Katharesan, V., & Corrigan, F. (2018). The effect of an acute systemic inflammatory insult on the chronic effects of a single mild traumatic brain injury. Behavioural brain research, 336, 22-31.https://www.sciencedirect.com/science/article/pii/S0166432817312846
20. Russo, M. V., & McGavern, D. B. (2016). Inflammatory neuroprotection following traumatic brain injury. Science, 353(6301), 783-785.https://science.sciencemag.org/content/353/6301/783.abstract
21. Thiel, A., & Heiss, W. D. (2011). Topical Review: Imaging.https://pdfs.semanticscholar.org/de47/136aa62cd53db19cd3bfb84c0ace8d58bb3d.pdf
22. Magaki, S. D., Williams, C. K., & Vinters, H. V. (2018). Glial function (and dysfunction) in the normal & ischemic brain. Neuropharmacology, 134, 218-225.https://www.sciencedirect.com/science/article/pii/S002839081730518X
23. Drew, P. D., & Kane, C. J. (2014). Fetal alcohol spectrum disorders and neuroimmune changes. In International review of neurobiology (Vol. 118, pp. 41-80). Academic Press. https://www.sciencedirect.com/science/article/pii/B9780128012840000038
24. Hay, J., Johnson, V. E., Smith, D. H., & Stewart, W. (2016). Chronic traumatic encephalopathy: the neuropathological legacy of traumatic brain injury. Annual Review of Pathology: Mechanisms of Disease, 11, 21-45.https://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-012615-044116
25. Karve, I. P., Taylor, J. M., & Crack, P. J. (2016). The contribution of astrocytes and microglia to traumatic brain injury. British journal of pharmacology, 173(4), 692-702.https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.13125
26. Vile, A. R., & Atkinson, L. (2017). Chronic Traumatic Encephalopathy: The cellular sequela to repetitive brain injury. Journal of Clinical Neuroscience, 41, 24-29. https://www.sciencedirect.com/science/article/pii/S0967586817300668
27. Ma, Y., Wang, J., Wang, Y., & Yang, G. Y. (2017). The biphasic function of microglia in ischemic stroke. Progress in neurobiology, 157, 247-272.https://www.sciencedirect.com/science/article/pii/S0301008215300708
28. Maccioni, R. B., González, A., Andrade, V., Cortés, N., Tapia, J. P., & Guzmán-Martínez, L. (2018). Alzheimer s disease in the perspective of neuroimmunology. The open neurology journal, 12, 50.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040210/
29. Doty, K. R., Guillot-Sestier, M. V., & Town, T. (2015). The role of the immune system in neurodegenerative disorders: adaptive or maladaptive?. Brain research, 1617, 155-173.https://www.sciencedirect.com/science/article/pii/S0006899314011950
30. Makinde, H. M., Just, T. B., Cuda, C. M., Perlman, H., & Schwulst, S. J. (2017). The role of microglia in the etiology and evolution of chronic traumatic encephalopathy. Shock (Augusta, Ga.), 48(3), 276. https://www.ncbi.nlm.nih.gov/pmc/articles/pmc5555778/
31. McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E. (2015). The neuropathology of chronic traumatic encephalopathy. Brain pathology, 25(3), 350-364.https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12248
32. Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017). Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron, 95(6), 1246-1265. https://www.sciencedirect.com/science/article/pii/S0896627317306128
33. Muccigrosso, M. M., Ford, J., Benner, B., Moussa, D., Burnsides, C., Fenn, A. M., ... & Godbout, J. P. (2016). Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge. Brain, behavior, and immunity, 54, 95-109.https://www.sciencedirect.com/science/article/pii/S0889159116300083
34. Perry, V. H. (2010). Contribution of systemic inflammation to chronic neurodegeneration. Acta neuropathologica, 120(3), 277-286. https://link.springer.com/article/10.1007/s00401-010-0722-x
35. Calcia, M. A., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016). Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness. Psychopharmacology, 233(9), 1637-1650.https://link.springer.com/content/pdf/10.1007/s00213-016-4218-9.pdf
36. Lim, J. S., & Kwon, H. M. (2010). Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives. Clinical interventions in aging, 5, 239https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938031/
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38. Napoli, I., & Neumann, H. (2010). Protective effects of microglia in multiple sclerosis. Experimental neurology, 225(1), 24-28. https://www.sciencedirect.com/science/article/pii/S0014488609001599
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40. Kerner, N. A., & Roose, S. P. (2016). Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms. The American Journal of Geriatric Psychiatry, 24(6), 496-508..https://www.sciencedirect.com/science/article/pii/S1064748116001378
Lifestyle and dietary approach to Neuroinflammation
1. Rea, K., Dinan, T. G., & Cryan, J. F. (2016). The microbiome: a key regulator of stress and neuroinflammation. Neurobiology of stress, 4, 23-33.https://www.sciencedirect.com/science/article/pii/S2352289515300370
2. Kim, Y. K., & Won, E. (2017). The influence of stress on neuroinflammation and alterations in brain structure and function in major depressive disorder. Behavioural brain research, 329, 6-11.https://www.sciencedirect.com/science/article/pii/S0166432817303303
3. Calcia, M. A., Bonsall, D. R., Bloomfield, P. S., Selvaraj, S., Barichello, T., & Howes, O. D. (2016). Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness. Psychopharmacology, 233(9), 1637-1650.https://link.springer.com/content/pdf/10.1007/s00213-016-4218-9.pdf
4. Bellesi, M., de Vivo, L., Chini, M., Gilli, F., Tononi, G., & Cirelli, C. (2017). Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex. Journal of Neuroscience, 37(21), 5263-5273.https://www.jneurosci.org/content/37/21/5263?utm_source=TrendMD&utm_medium=cpc&utm_campaign=JNeurosci_TrendMD_1
5. Bernier, M., Wahl, D., Ali, A., Allard, J., Faulkner, S., Wnorowski, A., ... & Tarantini, S. (2016). Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet. Aging (Albany NY), 8(5), 899.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931843/
6. Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A., Xue, Z., ... & Xie, Z. (2012). Sleep disturbance induces neuroinflammation and impairment of learning and memory. Neurobiology of disease, 48(3), 348-355.https://www.sciencedirect.com/science/article/pii/S0969996112002379
7. Piirainen, S., Youssef, A., Song, C., Kalueff, A. V., Landreth, G. E., Malm, T., & Tian, L. (2017). Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?. Neuroscience & Biobehavioral Reviews, 77, 148-164.https://www.sciencedirect.com/science/article/pii/S0149763416304857
8. Spielman, L. J., Little, J. P., & Klegeris, A. (2016). Physical activity and exercise attenuate neuroinflammation in neurological diseases. Brain Research Bulletin, 125, 19-29.https://www.sciencedirect.com/science/article/pii/S0361923016300557
9. Guillemot-Legris, O., & Muccioli, G. G. (2017). Obesity-induced neuroinflammation: beyond the hypothalamus. Trends in Neurosciences, 40(4), 237-253.https://www.sciencedirect.com/science/article/pii/S0166223617300255
10. Miller, A. A., & Spencer, S. J. (2014). Obesity and neuroinflammation: a pathway to cognitive impairment. Brain, behavior, and immunity, 42, 10-21.https://www.sciencedirect.com/science/article/pii/S0889159114000889
11. Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., ... & Kiliaan, A. J. (2017). Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing research reviews, 35, 222-240.https://www.sciencedirect.com/science/article/pii/S1568163716301027
12. Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., ... & Kiliaan, A. J. (2017). Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing research reviews, 35, 222-240.https://www.sciencedirect.com/science/article/pii/S1568163716301027
13. Kang, E. B., Koo, J. H., Jang, Y. C., Yang, C. H., Lee, Y., Cosio‐Lima, L. M., & Cho, J. Y. (2016). Neuroprotective Effects of Endurance Exercise Against High‐Fat Diet‐Induced Hippocampal Neuroinflammation. Journal of neuroendocrinology, 28(5).https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12385
14. Moreno-Navarrete, J. M., Blasco, G., Puig, J., Biarnes, C., Rivero, M., Gich, J., ... & Garcia-Castro, F. (2017). Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance. International Journal of Obesity, 41(11), 1627-1635.https://www.nature.com/articles/ijo2017162
15. Buric, I., Farias, M., Jong, J., Mee, C., & Brazil, I. A. (2017). What is the molecular signature of mind–body interventions? A systematic review of gene expression changes induced by meditation and related practices. Frontiers in Immunology, 8, 670.https://www.frontiersin.org/articles/10.3389/fimmu.2017.00670/full?source=post_page---------------------------
16. Nadjar, A., Wigren, H. K. M., & Tremblay, M. E. (2017). Roles of microglial phagocytosis and inflammatory mediators in the pathophysiology of sleep disorders. Frontiers in cellular neuroscience, 11, 250.https://www.frontiersin.org/articles/10.3389/fncel.2017.00250/full
17. Kalsbeek, M. J., Mulder, L., & Yi, C. X. (2016). Microglia energy metabolism in metabolic disorder. Molecular and cellular endocrinology, 438, 27-35.https://www.sciencedirect.com/science/article/pii/S0303720716304026
18. Valdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014). Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell reports, 9(6), 2124-2138.https://www.sciencedirect.com/science/article/pii/S2211124714009723
19. Tse, J. K. (2017). Gut microbiota, nitric oxide, and microglia as prerequisites for neurodegenerative disorders. ACS chemical neuroscience, 8(7), 1438-1447. https://pubs.acs.org/doi/abs/10.1021/acschemneuro.7b00176
20. Peng, H., Nickell, C. R. G., Chen, K. Y., McClain, J. A., & Nixon, K. (2017). Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats. Alcohol, 62, 29-40. https://www.sciencedirect.com/science/article/pii/S0741832916306322
21. Manchanda, S., Singh, H., Kaur, T., & Kaur, G. (2018). Low-grade neuroinflammation due to chronic sleep deprivation results in anxiety and learning and memory impairments. Molecular and cellular biochemistry, 449(1-2), 63-72. https://link.springer.com/article/10.1007/s11010-018-3343-7
22. Yin, Z., Raj, D. D., Schaafsma, W., van der Heijden, R. A., Kooistra, S. M., Reijne, A. C., ... & Yi, C. X. (2018). Low-fat diet with caloric restriction reduces white matter microglia activation during aging. Frontiers in molecular neuroscience, 11, 65.https://www.frontiersin.org/articles/10.3389/fnmol.2018.00065/full?_ga=2.22854206.449367120.1527552000-1350799375.1527552000
23. Valero, J., Paris, I., & Sierra, A. (2016). Lifestyle shapes the dialogue between environment, microglia, and adult neurogenesis. ACS chemical neuroscience, 7(4), 442-453.https://pubs.acs.org/doi/abs/10.1021/acschemneuro.6b00009
24. Piao, C. S., Stoica, B. A., Wu, J., Sabirzhanov, B., Zhao, Z., Cabatbat, R., ... & Faden, A. I. (2013). Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury. Neurobiology of disease, 54, 252-263.https://www.sciencedirect.com/science/article/pii/S0969996113000089
25. Simeone, T. A., Simeone, K. A., & Rho, J. M. (2017). Ketone bodies as anti-seizure agents. Neurochemical research, 42(7), 2011-2018.https://link.springer.com/article/10.1007/s11064-017-2253-5
26. Jeong, E. A., Jeon, B. T., Shin, H. J., Kim, N., Lee, D. H., Kim, H. J., ... & Roh, G. S. (2011). Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. Experimental neurology, 232(2), 195-202. https://www.sciencedirect.com/science/article/pii/S0014488611003086
27. Cullingford, T. E. (2004). The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. Prostaglandins, leukotrienes and essential fatty acids, 70(3), 253-264. https://www.sciencedirect.com/science/article/pii/S0952327803002163
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